Biomarkers

Led by Professor Caroline Relton, Professor George Davey Smith and  Professor Deborah Lawlor

Biomarkers are molecules, genes, or characteristics that can indicate someone is in a particular biological state, for example, that they have a disease. We help to incorporate biomarker measurements into a range of studies conducted by BRC researchers. We also ensure new technological developments relevant to biomarker analyses are embraced and evaluated at an early stage to keep our research up to date.

Some examples of our projects are:

  • Supporting the evaluation of a novel diagnostic biomarker for gestational diabetes (diabetes that some women develop during pregnancy)
  • Using biomarkers to assess the health and wellbeing of children born through in vitro fertilisation (IVF). This work will help our researchers to understand the factors that predict IVF success.
  • Using biomarkers to predict the effect of birth hypoxia (when a baby receives insufficient oxygen to their brain before, during, or after delivery) on the health of the baby later in life.
  • Working to identify the young people who have the greatest risk of developing psychotic experiences, those transitioning from self-harm to suicide and predictors of response to psychological therapy for post-traumatic stress disorder (PTSD). All these research topics involve identifying clinically useful biomarkers that can act as indicators of these mental disorders
  • Supporting researchers to analyse data (genotypic and molecular phenotypic) to predict surgical complications including those at risk of severe bleeding and Acute Kidney Injury (AKI).
  • Using biomarkers to identify men with prostate cancer most likely to benefit from changes to their diet and lifestyle.