Translational data science
Using large-scale genetic and other molecular data and electronic health record infrastructure to transform health.
A scientist working at a computer and writing on a pad
Drawing on Bristol’s expertise in big data, this theme brings together large, complex datasets. This enables us to develop and evaluate health interventions and predict how disease will develop.
Our work focuses on both analytical expertise and data infrastructure. Infrastructure includes data management software, platforms and integrating different organisations’ datasets. Our approach enables routine and research datasets to be combined and analysed using state-of-the-art methods.
This theme combines our:
- Innovative methods and software for large-scale genetic and molecular data analysis
- Electronic health record data infrastructure and analytical expertise
Using these, we aim to:
- Prioritise targets for intervention to prevent and treat disease
- Identify new biomarkers (biological molecules found in the blood or elsewhere in the body) that predict disease
We are building on cutting-edge research by the MRC Integrative Epidemiology Unit. We will also draw on data from large population-based studies with rich genetic, molecular and phenotypic (characteristics we can see, such as red hair) data. These include UK Biobank, Global Biobank Meta-analysis Initiative, Children of the 90s and the multi-ethnic Born-in-Bradford.
To address the needs of under-represented groups, we are developing new data analysis methods. We will apply these to a range of population health datasets from the UK and around the world.
Platforms such as OpenSAFELY and the UK Longitudinal Linkage Collaboration will allow us to analyse whole population linked administrative data. Administrative data includes information collected by public services and institutions such as the NHS and local authorities.
Our expert analysts will work with other Bristol BRC themes and external partners, to ensure everyone can benefit from our innovative approaches.
View all research projects from this theme
Using biomarkers and machine learning to predict antidepressant resistance
Theme Translational data science
Workstream Omics for prediction and prognosis
Can DNA methylation biomarkers predict whether pleural effusion is caused by cancer?
Theme Translational data science
Workstream Omics for prediction and prognosis
Using DNA methylation biomarkers to understand Parkinson’s disease severity and progression
Theme Translational data science
Workstream Omics for prediction and prognosis
PhD opportunity with Bristol BRC and Health Data Research UK
- 30 May 2023
Forecasting long-term demand in emergency departments
- 8 February 2023
Pfizer-BioNTech and AstraZeneca vaccines offer high protection against severe COVID-19, 6 months after second doses, finds study of over 7 million adults
- 21 July 2022